What is a good argument that could be used in an essay to describe the impact of fuku and what Junot Diaz is saying about it in this novel?

In The Brief Wondrous Life of Oscar
Wao, the Watcher (the older Yunior) first mentions the
fuku in the footnotes.  This curse is linked to the rotten luck of
Oscar's family, Trujillo, and even the Kennedy clan.   He says it starts with Columbus,
when he brought syphilis to the New World.  Ironically, a Scientific
American article (January 15, 2008) “Did Columbus Bring Syphilis to Europe?”
confirms that he might have.

After reading the novel, the
fuku becomes a leitmotif that could be any of the
following:

• a curse
  


• fate


• sexism


• Trujillo


• machismo


• venereal
  disease


• the "f#*k
  you"

Diaz arranges the novel in reverse
chronological order to show how the curse has affected the DeLeons: first with Lola,
then Beli, and on to Abelard Cabral’s decision to hide his wife and daughter in Chapter
5.

Finally, Oscar's quest for love is materialized when he
makes the redemptive sacrifice of tracing the fuku back to its
source, in the DR, and--with his death--ends it.