How do Lady Macbeth and Macbeth drift apart after the murder scene of Macbeth?

Prior to Duncan's murder, Lady Macbeth is in charge and
telling Macbeth the plans.  He must be persuaded to murder King Duncan.  After the
killing of Duncan, Macbeth takes control and leaves Lady Macbeth out of the planning of
future murders.  She tells him to enjoy being King, and he tells her that he cannot.  He
is too worried about the threats, real and imaginary, of others to be satisfied with
what he has achieved.

He hires murderers to kill Banquo and
Fleance.  He does not even consult her on this plan or inform her of his desires.  He
tells her to "be innocent of the knowledge, dearest Chuck" and talks to the murderers
alone. 

Next, he decides to have Macduff's entire family
killed and sends murderers to complete this job, as well.  Again, he never consults Lady
Macbeth or advises her of the plan. 

These murders lead to
Lady Macbeth losing her mind and sleepwalking because of the guilt.  When Macbeth is
told of her problem, he just tells the doctor to take care of
it. 

When Lady Macbeth commits suicide, Macbeth says that
he wishes he had the time to mourn her properly, but he is too busy with the problems at
hand.

These events indicate how the two drifted apart after
Duncan's murder. Macbeth is the one who decided to go on without Lady Macbeth's help and
advice.